Aseptic loosening is one of the major reasons for the need of revision surgery. As checked, the recalled
implants are Cobalt – Chrome – Molybdenum (CoCrMo). The term used of biocorrosion is ALVAL – Aseptic Lymphocyte Dominated Vasculitis Associated Lesion. During my PhD studies, we were strong advocates for the role of osteoclasts and immune cells in actively corroding the metal implants.
Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening–current concepts.Cadosch D, Chan E, Gautschi OP, Filgueira L.
School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia. firstname.lastname@example.org
Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants.
Maybe they should have paid a bit more attention to us researchers…..